Dr Suneil Raju  The clinical use for GIPs

GIPs are gluten immunogenic peptides that are resistant to gastrointestinal digestion. They are excreted in the urine and stool and as a result, there is a growing interest in them. A non-invasive test, the lateral flow device, can be used to detect urine GIPs making it quick and easy to do, but what is its clinical use? 

The current options for checking adherence are through dietary questionnaires and serological markers. The gold standard to test for villous atrophy is a gastroscopy with duodenal biopsies. The relationship between questionnaires and serological markers and the presence of villous atrophy is poor, could GIP be used to assess for adherence or villous atrophy?   


Dr Suneil Raju Dr Sunny Raju is a Clinical Research Fellow working in Sheffield. He graduated in 2015 from the University of Sheffield. Sunny is involved in clinical research in coeliac disease with a particular interest in diagnostic tests and treating the complications and associations of coeliac disease. 

He is the former Chair of the British Society of Gastroenterology Trainees Section and a member of the Changing Face of Medicine Faculty, focussing on the training and development of future doctors.