Unfortunately, we don't know why some coeliac patients develop gluten ataxia and other neurological symptoms. It seems that the antibodies that are produced in the gut in response to gluten can sometimes travel to the brain or nervous system and cause damage there. We are learning more and more that there is a connection between the gut and the brain (called the gut-brain-axis), however research is still studying the basics of this connection. It's not clear how the gut-brain-axis is affected in coeliac patients and if the patients genetic background could affect this. What we want to do in the future is link the gut-on-chip to a brain-on-chip and see if we can model the coeliac disease specific gut-brain-axis. However, we are not there yet and anticipate that this will take some years to set up.