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  4. High dimensional analysis of the mucosal immune system in coeliac disease; towards personalised treatment

High dimensional analysis of the mucosal immune system in coeliac disease; towards personalised treatment

Principal Investigator: Professor Frits Koning

Institution: Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre

Research classification: Aetiology, understanding the cause, risk or development of disease

Project start & duration: January 2016 (24 months)

Grant awarded: £50k

The severity of coeliac disease differs greatly between people which, in part, is due to genetic differences. Variances in the response of immune cells, associated with the damage to the gut, may also explain individual differences in disease severity.

For this project, biopsy samples from children and adults with coeliac disease will be compared with samples from those without coeliac disease. They will be analysed using novel technology already established in the researcher’s laboratory.

It is anticipated that the results from this project will provide new information on the involvement of specific immune cells, providing a greater understanding of the development of the disease and possible prevention strategies or new target areas for personal treatment.

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